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Presenting with polydipsia and polyuria and diagnosed with central diabetes insipidus, the 75-year-old woman had a 5-year history of controlled type 2 diabetes mellitus.


Nobumasa Ohara, Toshinori Takada , Yasuhiro Seki, Katsuhiko Akiyama ,Yuichiro Yoneoka

Department of Endocrinology and Metabolism, Uonuma Kikan Hospital, Minamiuonuma, Niigata, Japan,

Correspondence to Author:  Nobumasa Ohara


Background : A rare condition known as central diabetes insipidus (or CDI) is characterized by excessively diluted urine due to a deficiency in antidiuretic hormone. It is uncommon for diabetes mellitus and CDI to coexist without hereditary conditions like Wolfram syndrome. Diagnosing this combination of illnesses is crucial but also difficult because thirst, polydipsia, and polyuria are the symptoms of both conditions. There have been a few documented instances of CDI occurring in people with type 2 diabetes mellitus (T2D). We describe a unique instance of CDI that occurred in a T2D patient who was older. This paper seeks to explore indicators for the early diagnosis of CDI in T2D and to explain the clinical course.
Case Report : T2D symptoms, such as thirst, polydipsia, and polyuria, were experienced by a 70-year-old Japanese woman. The symptoms and hyperglycemia improved with the onset of medical treatment. Between 9% and 6% was the drop in the glycated hemoglobin level. Still, she maintained stable glycemic control, but five years later, at the age of seventyfive, she reverted to polydipsia, polyuria, and thirst. (6.3 L/ day), which is a considerable amount of urine. An analysis of urine glucose came back negative. In contrast to the urine, which had a low osmolality of 125 mOsm/kg, the plasma had a high osmolality of 321 ma. It was determined that CDI was the cause of a substantial rise in urine osmolality when vasopressin was administered. Effective symptom relief was obtained with desmopressin treatment.
T2D, this case emphasizes the importance of treating CDI as an uncommon but significant concomitant illness, especially in those who present with thirst, polydipsia, and polyuria despite well-controlled glycemia.
Central Diabetes Insipidus • Desmopressin • Polyuria • Type 2 Diabetes Mellitus


Nobumasa Ohara. Presenting with polydipsia and polyuria and diagnosed with central diabetes insipidus, the 75-year-old woman had a 5-year history of controlled type 2 diabetes mellitus.. Clinical Imaging and Case Reports 2023.

Journal Info

  • Journal Name: Clinical Imaging and Case Reports
  • Impact Factor: 2.709**
  • ISSN: 2770-9205
  • DOI: 10.52338/cicaserep
  • Short Name: CICASEREP
  • Acceptance rate: 55%
  • Volume: 6 (2024)
  • Submission to acceptance: 25 days
  • Acceptance to publication: 10 days


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