Pharmacokinetic and Pharmacodynamic Evaluation of a Sodium Bicarbonate Combination of Rabeprazole, a Proton-Pump Inhibitor, in HealthySubjects

Proton-pump inhibitors, including rabeprazole, are
susceptible to stomach acid breakdown. The use of entericcoated (EC) formulations reduces this issue, although their
slower onset time is a drawback. A Fixed-Dose Combination
(FDC) tablet containing rabeprazole and sodium bicarbonate,
which was utilised to elevate the intragastric pH, was
compared to a traditional extended-release